Humane Society International leads the multi-stakeholders Animal Free Safety Assessment Collaboration brings together corporate and non-profit leaders who share the goal of accelerating a modern, species-relevant approach to safety assessment globally to better protect people and our planet, and hasten the replacement of animal testing. The collaboration has been successfully acting as an independent facilitator or ‘honest broker’ for various projects promoting regulatory alignment and implementation of non animal testing approaches for human and veterinary vaccines and biologicals: https://www.afsacollaboration.org/biologicals/